Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00123
Keywords
C-type lectin receptor; fungal infection; signaling pathways; posttranslational modifications; immunity
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Funding
- US National Institutes of Health [R01 AI090901, AI121196, 123253]
- American Heart Association (AHA Great Rivers Associate Grant-in-Aid grant) [16GRT2699004]
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Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of anti-fungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.
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