Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00168
Keywords
signal transducer and activator of transcription 3; T cells; B cells; immunodeficiency; immune dysregulation
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [1127157, 1108800, 1088215, 1027400]
- National Health and Medical Research Council [1038881]
- NSW Ministry of Health under the NSW Health
- Australian Postgraduate Award
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Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4(+) and CD8(+) T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.
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