Related references
Note: Only part of the references are listed.Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming
Ramon I. Klein Geltink et al.
IMMUNITY (2017)
Glutathione Primes T Cell Metabolism for Inflammation
Tak W. Mak et al.
IMMUNITY (2017)
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
Tao Xu et al.
NATURE (2017)
Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity
Katrina J. Binger et al.
FRONTIERS IN IMMUNOLOGY (2017)
The role of AMPK in T cell metabolism and function
Eric H. Ma et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
mTOR signaling in the differentiation and function of regulatory and effector T cells
Hu Zeng et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
Dysfunctional T cell metabolism in the tumor microenvironment
Kathryn E. Beckermann et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2017)
Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease
Chirag H. Patel et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
Metabolic Instruction of Immunity
Michael D. Buck et al.
CELL (2017)
Serine Is an Essential Metabolite for Effector T Cell Expansion (vol 25, pg 345, 2017)
Eric H. Ma et al.
CELL METABOLISM (2017)
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Michael D. Buck et al.
CELL (2016)
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger et al.
CELL (2016)
Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Noga Ron-Harel et al.
CELL METABOLISM (2016)
Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells
Thiruvaimozhi Abimannan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
The role of glutathione reductase and related enzymes on cellular redox homoeostasis network
Narciso Couto et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells
Yu Wang et al.
IMMUNITY (2016)
NADPH Oxidase-Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses
Lindsey E. Padgett et al.
JOURNAL OF IMMUNOLOGY (2016)
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
Junyoung O. Park et al.
NATURE CHEMICAL BIOLOGY (2016)
PARADOXICAL ROLES OF ANTIOXIDANT ENZYMES: BASIC MECHANISMS AND HEALTH IMPLICATIONS
Xin Gen Lei et al.
PHYSIOLOGICAL REVIEWS (2016)
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
Mulki Angela et al.
NATURE COMMUNICATIONS (2016)
From Krebs to clinic: glutamine metabolism to cancer therapy
Brian J. Altman et al.
NATURE REVIEWS CANCER (2016)
A guide to immunometabolism for immunologists
Luke A. J. O'Neill et al.
NATURE REVIEWS IMMUNOLOGY (2016)
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
John P. Ray et al.
IMMUNITY (2015)
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
Martin Kolev et al.
IMMUNITY (2015)
Mitochondria in the Regulation of Innate and Adaptive Immunity
Samuel E. Weinberg et al.
IMMUNITY (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine
Aiping Bai et al.
NATURE COMMUNICATIONS (2015)
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis et al.
NATURE COMMUNICATIONS (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
Valerie A. Gerriets et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
T cells and reactive oxygen species
Aleksey V. Belikov et al.
JOURNAL OF BIOMEDICAL SCIENCE (2015)
ROS Function in Redox Signaling and Oxidative Stress
Michael Schieber et al.
CURRENT BIOLOGY (2014)
The thioredoxin antioxidant system
Jun Lu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Mitochondria as Oxidative Signaling Organelles in T-cell Activation: Physiological Role and Pathological Implications
Marcin M. Kaminski et al.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
Laura A. Sena et al.
IMMUNITY (2013)
Mitochondrial ROS Fire Up T Cell Activation
Michael P. Murphy et al.
IMMUNITY (2013)
Metabolic Pathways in Immune Cell Activation and Quiescence
Erika L. Pearce et al.
IMMUNITY (2013)
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Christopher T. Hensley et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. M. Tannahill et al.
NATURE (2013)
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Yoko Kidani et al.
NATURE IMMUNOLOGY (2013)
Modulation of oxidative stress as an anticancer strategy
Chiara Gorrini et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
The Glutamate–Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation
Leif Hertz
Frontiers in Endocrinology (2013)
Decreased STAT5 phosphorylation and GATA-3 expression in NOX2-deficient T cells: Role in T helper development
Kristen E. Shatynski et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J. W. van der Windt et al.
IMMUNITY (2012)
Metabolic reprogramming and metabolic dependency in T cells
Ruoning Wang et al.
IMMUNOLOGICAL REVIEWS (2012)
Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose
Yatao Du et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
David K. Finlay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling
Liang Zhi et al.
JOURNAL OF IMMUNOLOGY (2012)
Physiological Roles of Mitochondrial Reactive Oxygen Species
Laura A. Sena et al.
MOLECULAR CELL (2012)
Metabolic checkpoints in activated T cells
Ruoning Wang et al.
NATURE IMMUNOLOGY (2012)
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase
Yijun Wang et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Metabolic pathways in T cell fate and function
Valerie A. Gerriets et al.
TRENDS IN IMMUNOLOGY (2012)
Activated human CD4+ T cells express transporters for both cysteine and cystine
Trine Boegh Levring et al.
SCIENTIFIC REPORTS (2012)
T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
Marcin M. Kaminski et al.
CELL REPORTS (2012)
Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress
Dimitrios Mougiakakos et al.
BLOOD (2011)
Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
Mireille Belanger et al.
CELL METABOLISM (2011)
Measuring EGSH and H2O2 with roGFP2-based redox probes
Bruce Morgan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
Metabolism, migration and memory in cytotoxic T cells
David Finlay et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation
Pankaj Kumar Mandal et al.
CANCER RESEARCH (2010)
The Thioredoxin-Thioredoxin Reductase System Can Function in Vivo as an Alternative System to Reduce Oxidized Glutathione in Saccharomyces cerevisiae
Shi-Xiong Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3
Eva-Maria Hanschmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity
Hubert M. Tse et al.
JOURNAL OF IMMUNOLOGY (2010)
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr et al.
JOURNAL OF IMMUNOLOGY (2010)
T Cell Activation
Jennifer E. Smith-Garvin et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis
Divya Purushothaman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
Christopher C. Franklin et al.
MOLECULAR ASPECTS OF MEDICINE (2009)
Regulation of glutathione synthesis
Shelly C. Lu
MOLECULAR ASPECTS OF MEDICINE (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
Bryson D. Bennett et al.
NATURE CHEMICAL BIOLOGY (2009)
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Steven J. Bensinger et al.
CELL (2008)
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
Sarah R. Jacobs et al.
JOURNAL OF IMMUNOLOGY (2008)
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
Jessica A. Wofford et al.
BLOOD (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
Anthony D. D'Souza et al.
MITOCHONDRION (2007)
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
Jun Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Novel role for mitochondria:: Protein kinase Cθ-dependent oxidative signaling organelles in activation-induced T-cell death
Marcin Kaminski et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
Karen Bedard et al.
PHYSIOLOGICAL REVIEWS (2007)
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Lasse K. Bak et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Glutamate cysteine ligase catalysis - Dependence on ATP and modifier subunit for regulation of tissue glutathione levels
Y Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress
A Takahashi et al.
JOURNAL OF IMMUNOLOGY (2005)
Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae
GG Perrone et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase
C Johansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
SH Jackson et al.
NATURE IMMUNOLOGY (2004)
Regulation of T-cell apoptosis by reactive oxygen species
DA Hildeman
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Why is glutathione (a tripeptide) synthesized by specific enzymes while TSH releasing hormone (TRH or thyroliberin), also a tripeptide, is produced as part of a prohormone protein?
D Ganguly et al.
IUBMB LIFE (2003)
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-I
LJ Matthias et al.
NATURE IMMUNOLOGY (2002)
The CD28 signaling pathway regulates glucose metabolism
KA Frauwirth et al.
IMMUNITY (2002)
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
G Angelini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: Selective regulation of mitogen-activated protein kinase activation and Fas ligand expression
S Devadas et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
IL-7 enhances the survival and maintains the size of naive T cells
JC Rathmell et al.
JOURNAL OF IMMUNOLOGY (2001)
Thioredoxin reductase
D Mustacich et al.
BIOCHEMICAL JOURNAL (2000)
Compartmentation of brain glutamate metabolism in neurons and glia
Y Daikhin et al.
JOURNAL OF NUTRITION (2000)