Related references
Note: Only part of the references are listed.Monoclonal Antibodies: A Review
Surjit Singh et al.
CURRENT CLINICAL PHARMACOLOGY (2018)
Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro
Ling Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability
Frederick W. Jacobsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Antibodies to watch in 2017
Janice M. Reichert
MABS (2017)
An Fc-Silenced IgG1 Format With Extended Half-Life Designed for Improved Stability
M. Jack Borrok et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Synergistic Effect of Cavitation and Agitation on Protein Aggregation
Tetsuo Torisu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Shipping-Induced Aggregation in Therapeutic Antibodies: Utilization of a Scale-Down Model to Assess Degradation in Monoclonal Antibodies
Marianna L. Fleischman et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Conformational and Colloidal Stabilities of Human Immunoglobulin G Fc and Its Cyclized Variant: Independent and Compensatory Participation of Domains in Aggregation of Multidomain Proteins
Seiki Yageta et al.
MOLECULAR PHARMACEUTICS (2017)
Modulating IgG effector function by Fc glycan engineering
Tiezheng Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Impact of IgG Fc-Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy
Hongcheng Liu et al.
BIOTECHNOLOGY PROGRESS (2017)
Engineered antibody CH2 domains binding to nucleolin: Isolation, characterization and improvement of aggregation
Dezhi Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon
Wentao Chen et al.
ACS CHEMICAL BIOLOGY (2016)
Impact of cell culture on recombinant monoclonal antibody product heterogeneity
Hongcheng Liu et al.
BIOTECHNOLOGY PROGRESS (2016)
Engineering antibody therapeutics
Mark L. Chiu et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
Optimization on Fc for Improvement of Stability and Aggregation Resistance
Xiaobo Chen et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)
IgG Fc Fragment as a Scaffold for Development of Targeted Therapeutics
Gordana W. Knopp et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)
Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside
Chantal Kuhn et al.
IMMUNOTHERAPY (2016)
Evaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept
Ick Hyun Cho et al.
MABS (2016)
Phage display-derived human antibodies in clinical development and therapy
Andre Frenzel et al.
MABS (2016)
Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability
Matthew J. Edgeworth et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Effects of a reduced disulfide bond on aggregation properties of the human IgG1 CH3 domain
Kazumasa Sakurai et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2015)
Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins
Liming Liu
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn
Tianlei Ying et al.
MABS (2015)
Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry
Ian C. Shieh et al.
MOLECULAR PHARMACEUTICS (2015)
Conformational and Colloidal Stabilities of Isolated Constant Domains of Human Immunoglobulin G and Their Impact on Antibody Aggregation under Acidic Conditions
Seiki Yageta et al.
MOLECULAR PHARMACEUTICS (2015)
AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures
Rafael Zambrano et al.
NUCLEIC ACIDS RESEARCH (2015)
Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies
Wilton B. Williams et al.
SCIENCE (2015)
Fc fusion as a platform technology: potential for modulating immunogenicity
Ditza Levin et al.
TRENDS IN BIOTECHNOLOGY (2015)
Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life
Ranajoy Majumdar et al.
MABS (2015)
Etanercept biosimilars
Valderilio F. Azevedo et al.
RHEUMATOLOGY INTERNATIONAL (2015)
Engineered Fc based antibody domains and fragments as novel scaffolds
Tianlei Ying et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)
Engineering disulfide bonds within an antibody
Yoshihisa Hagihara et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)
Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture
Masayoshi Onitsuka et al.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2014)
Physical Stability Comparisons of IgG1-Fc Variants: Effects of N-Glycosylation Site Occupancy and Asp/Gln Residues at Site Asn 297
Mohammad A. Alsenaidy et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Stability of Monoclonal Antibodies at High-Concentration: Head-to-Head Comparison of the IgG1 and IgG4 Subclass
Martin S. Neergaard et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Pharmacokinetics of Peptide-Fc Fusion Proteins
Benjamin Wu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Type I and type II Fc receptors regulate innate and adaptive immunity
Andrew Pincetic et al.
NATURE IMMUNOLOGY (2014)
PASTA 2.0: an improved server for protein aggregation prediction
Ian Walsh et al.
NUCLEIC ACIDS RESEARCH (2014)
Engineered Soluble Monomeric IgG1 CH3 Domain GENERATION, MECHANISMS OF FUNCTION, AND IMPLICATIONS FOR DESIGN OF BIOLOGICAL THERAPEUTICS
Tianlei Ying et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Generation and Comparative Characterization of Glycosylated and Aglycosylated Human IgG1 Antibodies
Dmitrij Hristodorov et al.
MOLECULAR BIOTECHNOLOGY (2013)
N-Terminal Truncation of an Isolated Human IgG1 CH2 Domain Significantly Increases Its Stability and Aggregation Resistance
Rui Gong et al.
MOLECULAR PHARMACEUTICS (2013)
Consequences of glycan truncation on Fc structural integrity
Patrick M. Buck et al.
MABS (2013)
Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display
Michael W. Traxlmayr et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
An integrated approach to extreme thermostabilization and affinity maturation of an antibody
Audrey D. McConnell et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc
Christoph Hasenhindl et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies
Santosh V. Thakkar et al.
PROTEIN SCIENCE (2013)
Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1
Zhongyu Zhu et al.
VIROLOGICA SINICA (2013)
Engineered antibody variable and constant domains as therapeutic candidates
Rui Gong et al.
PHARMACEUTICAL PATENT ANALYST (2013)
A C-terminal interdomain disulfide bond significantly stabilizes the Fc fragment of IgG
Gordana Wozniak-Knopp et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)
Effect of pH, Temperature, and Salt on the Stability of Escherichia coli- and Chinese Hamster Ovary Cell-Derived IgG1 Fc
Cynthia H. Li et al.
BIOCHEMISTRY (2012)
Fc-fusion proteins: new developments and future perspectives
Daniel M. Czajkowsky et al.
EMBO MOLECULAR MEDICINE (2012)
Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc
Ramil F. Latypov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Soluble Monomeric IgG1 Fc
Tianlei Ying et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Engineering Aggregation Resistance in IgG by Two Independent Mechanisms: Lessons from Comparison of Pichia pastoris and Mammalian Cell Expression
Jonas V. Schaefer et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing
Michael W. Traxlmayr et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Developability index: A rapid in silico tool for the screening of antibody aggregation propensity
Timothy M. Lauer et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Pharmacokinetics of engineered human monomeric and dimeric CH2 domains
Kurt R. Gehlsen et al.
MABS (2012)
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein et al.
NATURE (2012)
Stabilisation of the Fc Fragment of Human IgG1 by Engineered Intradomain Disulfide Bonds
Gordana Wozniak-Knopp et al.
PLOS ONE (2012)
Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn
Rui Gong et al.
PLOS ONE (2012)
Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange
Aming Zhang et al.
PHARMACEUTICAL RESEARCH (2012)
Engineering Aggregation-Resistant Antibodies
Joseph M. Perchiacca et al.
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 3 (2012)
Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: A comparative study with CHO produced materials
Liming Liu et al.
BIOLOGICALS (2011)
Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies
Veysel Kayser et al.
BIOTECHNOLOGY JOURNAL (2011)
Isolation and characterization of IgG1 with asymmetrical Fc glycosylation
Sha Ha et al.
GLYCOBIOLOGY (2011)
Shortened Engineered Human Antibody CH2 Domains INCREASED STABILITY AND BINDING TO THE HUMAN NEONATAL Fc RECEPTOR
Rui Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway
James G. Barnard et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
The impact of glycosylation on monoclonal antibody conformation and stability
Kai Zheng et al.
MABS (2011)
Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport
Yu Bai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Prediction of protein binding regions
Naresh Chennamsetty et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)
Acid-Induced Aggregation of Human Monoclonal IgG1 and IgG2: Molecular Mechanism and the Effect of Solution Composition
Sanjay B. Hari et al.
BIOCHEMISTRY (2010)
Structure and function of immunoglobulins
Harry W. Schroeder et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)
High Throughput Thermostability Screening of Monoclonal Antibody Formulations
Feng He et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
Prediction of Aggregation Prone Regions of Therapeutic Proteins
Naresh Chennamsetty et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding
Damian Houde et al.
MOLECULAR & CELLULAR PROTEOMICS (2010)
Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties
G. Wozniak-Knopp et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates
Heather Franey et al.
PROTEIN SCIENCE (2010)
A large library based on a novel (CH2) scaffold: Identification of HIV-1 inhibitors
Xiaodong Xiao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Physical Instability of a Therapeutic Fc Fusion Protein: Domain Contributions to Conformational and Colloidal Stability
Jonas L. Fast et al.
BIOCHEMISTRY (2009)
Receptor-Fc fusion therapeutics, traps, and MIMETIBODY™ technology
Chichi Huang
CURRENT OPINION IN BIOTECHNOLOGY (2009)
Engineered Human Antibody Constant Domains with Increased Stability
Rui Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Aggregation-Prone Motifs in Human Immunoglobulin G
Naresh Chennamsetty et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Conformational Implications of an Inversed pH-Dependent Antibody Aggregation
Natalie Perico et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Elucidation of Two Major Aggregation Pathways in an IgG2 Antibody
Nicholas Van Buren et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Engineered CH2 domains (nanoantibodies)
Dimiter S. Dimitrov
MABS (2009)
Predictive tools for stabilization of therapeutic proteins
Vladimir Voynov et al.
MABS (2009)
Glycosylation as a strategy to improve antibody-based therapeutics
Roy Jefferis
NATURE REVIEWS DRUG DISCOVERY (2009)
Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation
Vladimir Voynov et al.
PLOS ONE (2009)
Design of therapeutic proteins with enhanced stability
Naresh Chennamsetty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action
Royston Jefferis
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Structure of an isolated unglycosylated antibody CH2 domain
Ponraj Prabakaran et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2008)
Structural characterization of a human Fc fragment engineered for lack of effector functions
Vaheh Oganesyan et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2008)
Terminal sugars of Fc glycans influence antibody effector functions of IgGs
T. Shantha Raju
CURRENT OPINION IN IMMUNOLOGY (2008)
Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo
Ana P. Goncalvez et al.
JOURNAL OF VIROLOGY (2008)
Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody C(H)3 domain
Arnold MaAuley et al.
PROTEIN SCIENCE (2008)
High concentration formulation feasibility of human immunoglubulin G for subcutaneous administration
Bhas Dani et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1
Shigeki Matsumiya et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
A broad range of Fab stabilities within a host of therapeutic IgGs
Ellen Garber et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Highly concentrated monoclonal antibody solutions: Direct analysis of physical structure and thermal stability
N. Harn et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies
Daisuke Ejima et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
AGGRESCAN:: a server for the prediction and evaluation of hot spots of aggregation in polypeptides
Oscar Conchillo-Sole et al.
BMC BIOINFORMATICS (2007)
FcRn: the neonatal Fc receptor comes of age
Derry C. Roopenian et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
William F. Dall'Acqua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Glycosylation in the Fc domain of IgG increases resistance to proteolytic cleavage by papain
TS Raju et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Protein aggregation and amyloidosis: confusion of the kinds?
F Rousseau et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2006)
Protein aggregation and bioprocessing
Mary E. M. Cromwell et al.
AAPS JOURNAL (2006)
Glycosylation of recombinant antibody therapeutics
R Jefferis
BIOTECHNOLOGY PROGRESS (2005)
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody (vol 101, pg 17616, 2004)
DW Colby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Engineered antibody fragments and the rise of single domains
P Holliger et al.
NATURE BIOTECHNOLOGY (2005)
Human antibody - Fc receptor interactions illuminated by crystal structures
JM Woof et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542
JM Jacobson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Optimization of the antibody CH3 domain by residue frequency analysis of IgG sequences
SJ Demarest et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
AM Fernandez-Escamilla et al.
NATURE BIOTECHNOLOGY (2004)
A comparative study of the relationship between protein structure and β-aggregation in globular and intrinsically disordered proteins
R Linding et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Potent inhibition of huntingtin and cytotoxicity by a disulfide bond-free single-domain intracellular antibody
DW Colby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Folding mechanism of the CH2 antibody domain
MJ Feige et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
CD3-specific antibody-induced active tolerance: From bench to bedside
L Chatenoud
NATURE REVIEWS IMMUNOLOGY (2003)
Folding and oxidation of the antibody domain CH3
MJW Thies et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation
JS Richardson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Crystal structure of a neutralizing human IgG against HIV-1: A template for vaccine design
EO Saphire et al.
SCIENCE (2001)
The alternatively folded state of the antibody CH3 domain
MJW Thies et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Advances in immunology: Complement (Second of two parts).
MJ Walport
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Advances in immunology: Complement (First of two parts).
MJ Walport
NEW ENGLAND JOURNAL OF MEDICINE (2001)
High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR
RL Shields et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms
Y Mimura et al.
MOLECULAR IMMUNOLOGY (2000)