Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00270
Keywords
macrophage; immunometabolism; glycolysis; tricarboxylic acid cycle; electron transport chain
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Funding
- Science Foundation Ireland
- Wellcome Trust, UK
- Wellcome Trust [205455/14107]
- Science Foundation Ireland [12/IA/1531]
- Science Foundation Ireland (SFI) [12/IA/1531] Funding Source: Science Foundation Ireland (SFI)
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Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provides evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses-responses that in turn are a direct result of metabolic reprogramming. As we learn more about the precise role of metabolic pathways and pathway intermediates in immune function, a novel opportunity to target immunometabolism therapeutically has emerged. Here, we review the current understanding of the regulation of macrophage function through metabolic remodeling.
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