Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00609
Keywords
autoimmune hepatitis; primary biliary cholangitis; primary sclerosing cholangitis; antinuclear antibodies; smooth muscle antibodies; antimitochondrial antibodies; soluble liver antigen/liver-pancreas antigen; serology
Categories
Funding
- DFG [SE 2665/1-1, SFB841, KFO306]
- Helmut and Hannelore Greve Foundation
- YAEL Foundation
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Testing for liver-related autoantibodies should be included in the workup of patients with hepatitis or cholestasis of unknown origin. Although most of these autoantibodies are not disease specific, their determination is a prerequisite to diagnose autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), and they are components of the diagnostic scoring system in these diseases. In primary sclerosing cholangitis (PSC), on the other hand, autoantibodies are frequently present but play a minor role in establishing the diagnosis. In PSC, however, data on antibodies suggest a link between disease pathogenesis and the intestinal microbiota. This review will focus on practical aspects of antibody testing in the three major autoimmune liver diseases AIH, PBC, and PSC.
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