Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00598
Keywords
bacteria; antibody; particle; vaccine; polysaccharide; autoantibody; marginal zone; antigen presentation
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Funding
- N.I.H. [2R01-AI49192]
- U.S.U.H.S. Dean's Research and Education Endowment
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Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is also relevant regarding the use of therapeutic human proteins in clinical medicine that have been shown to aggregate, and perhaps as a result, elicit autoantibodies.
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