Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00547
Keywords
lymphocytes; homeostasis; T cells; proliferation; lymphopenia
Categories
Funding
- NIAID [AI125247, AI121524]
- NMSS [RG1411-02051]
- AAF [14-001]
- CCF
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Naive T lymphocytes undergo heterogeneous proliferative responses when introduced into lymphopenic hosts, referred to as homeostatic proliferation and spontaneous proliferation. Spontaneous proliferation is a unique process through which the immune system generates memory phenotype cells with increasing T cell receptors repertoire complexity. Here, the mechanisms that initiate and control spontaneous proliferation are discussed.
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