Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00225
Keywords
tuberculosis; Mycobacterium tuberculosis; dectin-1; C-type lectin receptors; innate immunity; TB immunity; pattern-recognition receptors; pathogen-associated molecular patterns
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Funding
- Wellcome Trust [206751/Z/17/Z]
- South African Medical Research Council (SAMRC)
- National Research Foundation
- SAMRC
- South African Department of Health
- University of Cape Town
- Carnegie Corporation DEAL fellowship
- National Research Foundation of South Africa
- Wellcome Trust [206751/Z/17/Z] Funding Source: Wellcome Trust
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One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.
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