Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01174
Keywords
immune synapse; cytoskeleton; T cell receptor; centrosome; dynein; dynactin; microtubule; molecular motor
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Funding
- Spanish Ministry of Economy and Competitiveness [SAF2014-55579-R, SAF 2017/82886-R]
- Comunidad de Madrid [CAM S2017/BMD-3671]
- Instituto de Salud Carlos III [PIE13/00041]
- European Regional Development Fund (ERDF)
- [ERC-2011-AdG 294340-GENTRIS]
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The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and organelle arrangements that support their specific tasks. In particular, T cells rapidly change their shape and cellular function through the establishment of cell surface and intracellular polarity in response to a variety of cues. This review focuses on the contribution of the microtubule-based dynein/dynactin motor complex, the tubulin and actin cytoskeletons, and different organelles to the formation of the antigen-driven immune synapse.
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