Journal
EMERGING INFECTIOUS DISEASES
Volume 17, Issue 12, Pages 2239-2244Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1712.110609
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Funding
- Natural Sciences and Engineering Research Council of Canada [154280, 380299]
- Minister of Economic Development, Innovation and Export Trade
- China-Quebec Collaboration grants [2008FA31830, 2008DFA31830]
- Canadian Institutes of Health Research
- Grants-in-Aid for Scientific Research [23580420] Funding Source: KAKEN
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We performed multilocus sequence typing of 64 North American Streptococcus suis serotype 2 porcine isolates. Strains were sequence type (ST) 28(51%), ST25 (44%), and ST1 (5%). We identified nonrandom associations between STs and expression of the virulence markers suilysin (SLY), muramidase-relased protein (MRP), and extracellular factor (EF). Expression of pill encoded by the srtF and srtG pilus clusters was also nonrandomly associated with STs. ST1 strains were SLY+ EF+ MIRP+ srtF pilus+ srtG pilus. ST25 strains were SLY- EF- MRP- srtF pilus- srtG pilus+, and most ST28 strains were SLY- MRP+ EF- srtF pilus+ srtG pilus+. ST28 isolates proved essentially nonvirulent in a mouse infection model; ST25 strains showed moderate virulence and ST1 isolates were highly virulent. ST1 is responsible for a high proportion of S. suis disease in humans worldwide. Its presence in North America indicates that potential zoonotic S. suis outbreaks in this continent cannot be disregarded.
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