Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
Volume 5, Issue 2, Pages 74-79Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.7b00561
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Funding
- National Natural Science Foundation of China (NSFC) [91543205, 41471418]
- Research Grants Council of Hong Kong [PolyU 152095/14E]
- Hong Kong Polytechnic University
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The atmosphere represents an unappreciated compartment for the environmental dissemination of antibiotic resistance genes (ARGs), particularly via airborne fine particles (PM2.5), with strong implications for the inhalational exposure of the general population. We examined the seasonal variations in airborne bacteria and several ARGs in PM2.5 across an industrial urban rural transect in a megacity of China over an annual cycle. Seasonality was most apparent at the rural site with a remarkable wintertime reduction in the total level of bacteria and an enrichment of certain ARGs in winter but dilution in spring. This contrasted with the relative consistency across seasons at urban and industrial sites. The statistical correlation between ARGs and the mobile genetic element (MGE), intI1, weakened from rural to urban and industrial sites, which hints at the diluting role of intI1 in horizontal gene transfers across the land use gradient. Differing mechanisms may regulate site-specific population exposure to transferable ARGs, and the identification of additional MGEs is warranted. Compared to drinking water and the accidental ingestion of agricultural soil, airborne PM2.5 contributes to a similar extent to the human daily intake of certain ARGs and intI1. Collectively, this study highlights the importance of PM2.5 in the dissemination of, and pathways of human exposure to, common environmental ARGs.
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