Journal
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
Volume 23, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s12199-018-0706-3
Keywords
Depleted uranium; Toxicity; Decorporation; Chelating agents
Categories
Funding
- National Science and Technology Major Project of China on Key New Drug Creation and Development Program [2014ZX09J14104-06C]
- Excellent Young Talents Support Program of Fourth Military Medical University
- Science & Technology Fund Planning Project of Fourth Military Medical University
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Depleted uranium (DU) has been widely applied in industrial and military activities, and is often obtained from producing fuel for nuclear reactors. DU may be released into the environment, polluting air, soil, and water, and is considered to exert both radiological and chemical toxicity. In humans and animals, DU can induce multiple health effects, such as renal tubular necrosis and bone malignancies. This review summarizes the known information on DU's routes of entry, mechanisms of toxicity, and health effects. In addition, we survey the chelating agents used in ameliorating DU toxicity.
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