Journal
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume 16, Issue 2, Pages 129-135Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2018.16.2.129
Keywords
Autism spectrum disorder; Wnt; Beta-catenin; Chromodomain helicase DNA binding protein 8; Neuronal development
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT & Future Planning) [NRF-2015R1C1A1A02036506]
Ask authors/readers for more resources
Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent technological advancements, such as next-generation sequencing, have led to the identification of certain loci that is responsible for the pathophysiology of ASD. Three functional pathways, such as chromatin remodeling, Wnt signaling and mitochondrial dysfunction are potentially involved in ASD. In this review, we will focus on recent studies of the involvement of Wnt signaling pathway components in ASD pathophysiology and related drugs used in ASD treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available