Journal
ADVANCED SCIENCE
Volume 5, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/advs.201700474
Keywords
biodegradable; blood brain barrier; brain tumor; focused ultrasound; theranostic
Categories
Funding
- National Key Basic Research Program of China (973 Program) [2015CB755500]
- National Nature Science Foundation of China [11534013, 81527901]
- China Postdoctoral Science Foundation [2017M610556]
- Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province [2014B030301013]
- Natural Science Foundation of Guangdong Province [2014A030312006, 2016A020213004]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170307165254568]
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The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging-guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu2-xSe particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor-triggered programmed destruction due to the reducing microenvironment-responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu2-xSe, resulting in tumor-specific biodegradation and on-demand drug-releasing behavior. Such tumor microenvironment-responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy.
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