Journal
ADVANCED SCIENCE
Volume 5, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/advs.201700609
Keywords
biodetection; energy acceptor; ions; small molecules; upconversion
Categories
Funding
- Academic Research Fund from the Ministry of Education, Singapore [RG13/15, RG 8/16, RG 114/16]
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Significant progress on upconversion-nanoparticle (UCNP)-based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non-autofluorescence, high chemical stability, large light-penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide-doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP-based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.
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