Journal
ACS INFECTIOUS DISEASES
Volume 4, Issue 3, Pages 291-300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.7b00201
Keywords
colistin resistance; MCR-1; mcr-like genes; global dissemination; plasmid reservoir
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Funding
- National Key R&D Program of China [2017YFD0500202]
- National Key Basic Research Program of China [2016YFC1200100]
- National Natural Science Foundation of China [31570027, 81772142]
- Young 1000 Talents Award
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Polymyxins, a group of cationic antimicrobial polypeptides, act as a last-resort defense against lethal infections by carbapenem-resistant Gram-negative pathogens. Recent emergence and fast spread of mobilized colistin resistance determinant mcr-1 argue the renewed interest of colistin in clinical therapies, threatening global public health and agriculture production. This mini-review aims to present an updated overview of mcr-1, covering its global dissemination, the diversity of its hosts/plasmid reservoirs, the complexity in the genetic environment adjacent to mcr-1, the appearance of new mcr-like genes, and the molecular mechanisms for mobilized colistin resistance determinant 1/2 (MCA-1/2).
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