Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 4, Pages 1272-1284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00738
Keywords
trachea mechanics; cartilage rings; annular ligament; trachealis muscle; tracheal compliance; structural anisotropy engineered trachea
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Trachea replacement.for nonoperable defects remains an unsolved problem due to complications with stenosis and mechanical insufficiency. While native trachea has anisotropic mechanical properties, the vast majority of engineered constructs focus on uniform cartilaginous-like conduits. These conduits often lack quantitative mechanical analysis at the construct level, which limits analysis of functional outcomes in vivo, as well as comparisons across studies. This review aims to present a dear picture of native tracheal mechanics at the tissue and organ level, as well as loading conditions to establish design criteria for trachea replacements. We further explore the implications of failing to match native properties with regards to implant collapse, stenosis, and infection.
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