Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 4, Pages 1386-1396Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00031
Keywords
peptide; hydrogel; self-assembly; diabetic ulcer; wound healing
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Funding
- Welch Foundation [C1557]
- NIH [NIDCR R01DE021798]
- NSF Graduate Research Fellowship Program [1450681]
- Mexican National Council for Science and Technology (CONACyT) Ph.D. Scholarship Program
- Stauffer-Rothrock Fellowship
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In vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded and a natural collagen-based extracellular matrix is produced remodeling the artificial material into natural tissue. These properties make MDPs particularly well suited for applications in regeneration. In this work, we test the regenerative potential of MDP hydrogels in a diabetic wound healing model. When applied to full-thickness dermal wounds in genetically diabetic mice, the MDP hydrogel resulted in significantly accelerated wound healing compared to a clinically used hydrogel, as well as a control buffer. Treatment with the MDP hydrogel resulted in wound dosure in 14 days, formation of thick granulation tissue including dense vascularization, innervation, and hair follicle regeneration. This suggests the MDP hydrogel could be an attractive choice for treatment of wounds in diabetic patients.
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