Journal
NUCLEUS
Volume 9, Issue 1, Pages 142-148Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2017.1395542
Keywords
Nuclear pore complex; Nucleoporin; nuclear transport; nuclear envelope; gene expression; transcription; Muscle
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Funding
- HHS \ NIH \ National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [R01AR065083]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR065083] Funding Source: NIH RePORTER
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Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity. In light of recent discoveries, NPCs are emerging as scaffolds that mediate the regulation of specific gene sets at the nuclear periphery. The function of NPCs as genome organizers and hubs for transcriptional regulation provides additional evidence that the compartmentalization of genes and transcriptional regulators within the nuclear space is an important mechanism of gene expression regulation.
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