Journal
NANOMATERIALS
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nano8040226
Keywords
carbon nanotube; DNA; biosensor
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Funding
- Creative Research Initiative Center for Bio-Artificial Muscle in Korea
- Air Force Office of Sponsored Research [FA9550-15-1-0273]
- Brigham and Women's Hospital
- Reny family
- Korea Institute of Industrial Technology, Republic of Korea [PEO18171]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1D1A1B03033694]
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The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors.
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