Journal
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume 33, Issue 3, Pages 483-489Publisher
KOREAN ASSOC INTERNAL MEDICINE
DOI: 10.3904/kjim.2016.227
Keywords
Antigen-presenting cells; Dendritic cells; Th2 responses
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science and Technology
- Ministry of Science, ICT & Future Planning [2014R1A1A1002131, NRF-2016R1E1A2020731, 2017R1A2B2003575]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) by the Ministry of Health and Welfare [HI17C0387]
- Korea University
- Korea University Medical Center
- Korea University Anam Hospital, Seoul, Republic of Korea [O1700021]
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A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, particularly dendritic cells (DCs), are mandatory for the induction of a Th cell response. Numerous studies have documented the organizing role of DCs in this process. The present review summarizes the fundamental roles of DCs in inducing Th2 responses.
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