Related references
Note: Only part of the references are listed.The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism
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p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis
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RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer
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RhoB Promotes Cancer Initiation by Protecting Keratinocytes from UVB-Induced Apoptosis but Limits Tumor Aggressiveness
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RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner
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Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration
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ONCOGENE (2013)
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RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor
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RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA
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The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells
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FEBS LETTERS (2011)
A distinct role of RhoB in gastric cancer suppression
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INTERNATIONAL JOURNAL OF CANCER (2011)
MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells
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RhoB enhances migration and MMP1 expression of prostate cancer DU145
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EXPERIMENTAL AND MOLECULAR PATHOLOGY (2010)
αvβ3/αvβ5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma
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CANCER RESEARCH (2009)
Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells
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CELLULAR SIGNALLING (2009)
RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells
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INTERNATIONAL JOURNAL OF CANCER (2009)
In vivo restoration of RhoB expression leads to ovarian tumor regression
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CANCER GENE THERAPY (2008)
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FEBS LETTERS (2008)
Mammalian Rho GTPases:: new insights into their functions from in vivo studies
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Regulation of glioblastoma cell invasion by PKCι and RhoB
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ONCOGENE (2008)
RhoB regulates PDGFR-β trafficking and signaling in vascular smooth muscle cells
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Epigenetic regulation of RhoB loss of expression in lung cancer
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RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line
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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
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ONCOGENE (2007)
Up-regulation of RhoB by glucocorticoids and its effects on the cell proliferation and NF-κB transcriptional activity
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HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway
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Activation of RhoB by hypoxia controls hypoxia-inducible factor-1 alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells
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RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling
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Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
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Loss of RhoB expression in human lung cancer progression
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Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors
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RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane
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Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase
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Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
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EXPERIMENTAL CELL RESEARCH (2004)
Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition
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Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer
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Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts
I Ader et al.
ONCOGENE (2003)
A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells
L Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development
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GENES & DEVELOPMENT (2003)
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line
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ONCOGENE (2003)
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
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JOURNAL OF CLINICAL ONCOLOGY (2003)
Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells
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INTERNATIONAL JOURNAL OF CANCER (2003)
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
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Phase II study of the farnesyl transferase inhibitor r115777 in patients with advanced non-small-cell lung cancer
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JOURNAL OF CLINICAL ONCOLOGY (2003)
Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
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Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo
J Halaschek-Wiener et al.
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Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
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BRITISH JOURNAL OF CANCER (2002)
RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death
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ONCOGENE (2002)
A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan
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ANNALS OF ONCOLOGY (2002)
The expression of Rho proteins decreases with human brain tumor progression: Potential tumor markers
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RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
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RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage
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Tumor hypoxia:: Definitions and current clinical, biologic, and molecular aspects
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors
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FEBS LETTERS (2000)
RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors
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MOLECULAR AND CELLULAR BIOLOGY (2000)
Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
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Regulation of endocytic traffic by Rho family GTPases
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Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)