Journal
FRONTIERS IN PHYSIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.00646
Keywords
regulatory network; logical model; discrete dynamics; regulatory circuit; p53-Mdm2 network
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia [PTDC/BEX-BCB/0772/2014, PTDC/EEI-CTP/2914/2014]
- French Plan Cancer, in the context of the project CoMET
- French Plan Cancer, in the context of the project SYSTAIM
- French Agence Nationale pour la Recherche [ANR-15-CE15-0006-01]
- Fundação para a Ciência e a Tecnologia [PTDC/BEX-BCB/0772/2014, PTDC/EEI-CTP/2914/2014] Funding Source: FCT
- Agence Nationale de la Recherche (ANR) [ANR-15-CE15-0006] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
