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Yuchen Chien et al.
GENES & DEVELOPMENT (2011)
Four faces of cellular senescence
Francis Rodier et al.
JOURNAL OF CELL BIOLOGY (2011)
Oxidative Stress Induces Senescence in Chondrocytes
Anita Brandl et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Klotho suppresses RIG-I-mediated senescence-associated inflammation
Feng Liu et al.
NATURE CELL BIOLOGY (2011)
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
Mohit Kapoor et al.
NATURE REVIEWS RHEUMATOLOGY (2011)
Caveolin-1, cellular senescence and age-related diseases
Huafei Zou et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2011)
SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
Zhiyong Mao et al.
SCIENCE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial-Lysosomal Axis Theory of Aging
Alexei Terman et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model
M. Almonte-Becerril et al.
APOPTOSIS (2010)
Mammalian Target of Rapamycin Signaling Is Crucial for Joint Destruction in Experimental Arthritis and Is Activated in Osteoclasts From Patients With Rheumatoid Arthritis
Daniel Cejka et al.
ARTHRITIS AND RHEUMATISM (2010)
Autophagy Is a Protective Mechanism in Normal Cartilage, and Its Aging-Related Loss Is Linked With Cell Death and Osteoarthritis
Beatriz Carames et al.
ARTHRITIS AND RHEUMATISM (2010)
Methods for detecting autophagy and determining autophagy-induced cell death
Yongqiang Chen et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2010)
Autophagy: cellular and molecular mechanisms
Danielle Glick et al.
JOURNAL OF PATHOLOGY (2010)
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Shomit Sengupta et al.
MOLECULAR CELL (2010)
A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen
Jean-Philippe Coppe et al.
PLOS ONE (2010)
Loss of Caveolin-1 Accelerates Neurodegeneration and Aging
Brian P. Head et al.
PLOS ONE (2010)
The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond
Sarah F. Funderburk et al.
TRENDS IN CELL BIOLOGY (2010)
Inflammatory networks during cellular senescence: causes and consequences
Adam Freund et al.
TRENDS IN MOLECULAR MEDICINE (2010)
Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
Michael Muller
ANTIOXIDANTS & REDOX SIGNALING (2009)
Regulation of Autophagy in Human and Murine Cartilage Hypoxia-Inducible Factor 2 Suppresses Chondrocyte Autophagy
Jolene Bohensky et al.
ARTHRITIS AND RHEUMATISM (2009)
SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree
Antero Salminen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway
Janine N. Bartholomew et al.
CANCER RESEARCH (2009)
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Tiara L. A. Kawahara et al.
CELL (2009)
Autophagy: Regulation and role in disease
Alfred J. Meijer et al.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2009)
Autophagy mediates the mitotic senescence transition
Andrew R. J. Young et al.
GENES & DEVELOPMENT (2009)
Angiogenic growth factors inhibit chondrocyte ageing in osteoarthritis: potential involvement of catabolic stress-induced overexpression of caveolin-1 in cellular ageing
Kazuo Yudoh et al.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo
Florence Debacq-Chainiaux et al.
NATURE PROTOCOLS (2009)
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
R. F. Loeser
OSTEOARTHRITIS AND CARTILAGE (2009)
Chromatin protein HMGB2 regulates articular cartilage surface maintenance via β-catenin pathway
Noboru Taniguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
Arturo V. Orjalo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
Narendra Wajapeyee et al.
CELL (2008)
Senescence of activated stellate cells limits liver fibrosis
Valery Krizhanovsky et al.
CELL (2008)
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy
Jiefei Geng et al.
EMBO REPORTS (2008)
Premature aging in mice activates a systemic metabolic response involving autophagy induction
Guillermo Marino et al.
HUMAN MOLECULAR GENETICS (2008)
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita et al.
NATURE (2008)
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Darren J. Baker et al.
NATURE CELL BIOLOGY (2008)
Differential effects of tumor necrosis factor-α and interleukin-1β on cell death in human articular chondrocytes
B. Carames et al.
OSTEOARTHRITIS AND CARTILAGE (2008)
Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis
C. M. Davies et al.
OSTEOARTHRITIS AND CARTILAGE (2008)
Autophagy and aging: keeping that old broom working
Ana Maria Cuervo
TRENDS IN GENETICS (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Telomere dysfunction and tumour suppression: the senescence connection
Yibin Deng et al.
NATURE REVIEWS CANCER (2008)
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi et al.
NATURE (2007)
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
S. J. Ryu et al.
CELL DEATH AND DIFFERENTIATION (2007)
Molecular dissection of formation of senescence-associated heterochromatin foci
Rugang Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
Valeria V. Orlova et al.
EMBO JOURNAL (2007)
Self-eating and self-killing: crosstalk between autophagy and apoptosis
M. Chiara Maiuri et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Loss of linker histone H1 in cellular senescence
Ryo Funayama et al.
JOURNAL OF CELL BIOLOGY (2006)
Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation
J. J. Tang et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2006)
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
M. J. Lopez-Armada et al.
OSTEOARTHRITIS AND CARTILAGE (2006)
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
Roderik M. Kortlever et al.
NATURE CELL BIOLOGY (2006)
Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1 - Possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis
SM Dai et al.
ARTHRITIS AND RHEUMATISM (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
JM Solomon et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
DB Stetson et al.
IMMUNITY (2006)
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all
Jesus Gil et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Apoptosis resistance of senescent human fibroblasts is correlated with the absence of nuclear IGFBP-3
B Hampel et al.
AGING CELL (2005)
Autophagy in cell death: an innocent convict?
B Levine et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Autophagy and aging -: The importance of maintaining clean cells
Ana Maria Cuervo et al.
AUTOPHAGY (2005)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes
E Maneiro et al.
ANNALS OF THE RHEUMATIC DISEASES (2005)
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
RG Zhang et al.
DEVELOPMENTAL CELL (2005)
Lipofuscin
A Terman et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Aging as a catabolic malfunction
A Terman et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Ink4a/Arf links senescence and aging
NE Sharpless
EXPERIMENTAL GERONTOLOGY (2004)
Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
HW Zhou et al.
RHEUMATOLOGY (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes
N Fukui et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2003)
The role of chondrocyte senescence in osteoarthritis
JS Price et al.
AGING CELL (2002)
Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
UT Brunk et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
The mitochondrial-lysosomal axis theory of aging - Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
UT Brunk et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Caveolin-1 expression negatively regulates cell cycle progression by inducing G0/G1 arrest via a p53/p21WAF1/Cip1-dependent mechanism
F Galbiati et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Telomere erosion and senescence in human articular cartilage chondrocytes
JA Martin et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilage
A McAlinden et al.
OSTEOARTHRITIS AND CARTILAGE (2001)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis
S Kaneko et al.
CYTOKINES CELLULAR & MOLECULAR THERAPY (2000)
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