Journal
FRONTIERS IN PHYSIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.00148
Keywords
cardiovascular system; circulation model; bond graph; CeIIML; OpenCOR; ADAN model; OD model; blood flow
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Funding
- Science for Technological Innovation (SfTI) National Science Challenge - New Zealand Government
- Brazilian agency CNPq
- Brazilian agency FAPERJ
- Medical Technologies Centre of Research Excellence (MedTech CoRE) - Tertiary Education Commission of New Zealand
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We propose a detailed CellML model of the human cerebral circulation that runs faster than real time on a desktop computer and is designed for use in clinical settings when the speed of response is important. A lumped parameter mathematical model, which is based on a one-dimensional formulation of the flow of an incompressible fluid in distensible vessels, is constructed using a bond graph formulation to ensure mass conservation and energy conservation. The model includes arterial vessels with geometric and anatomical data based on the ADAN circulation model. The peripheral beds are represented by lumped parameter compartments. We compare the hemodynamics predicted by the bond graph formulation of the cerebral circulation with that given by a classical one-dimensional Navier-Stokes model working on top of the whole-body ADAN model. Outputs from the bond graph model, including the pressure and flow signatures and blood volumes, are compared with physiological data.
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