Journal
FRONTIERS IN PHYSIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.00780
Keywords
courtship; copulation duration; Drosophila melanogaster; fruitless; serotonergic; dopaminergic
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Funding
- National Institute of General Medical Sciences Grants [R01 GM099883, R01 GM074675, R35 GM118137]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2014-06012]
- Cette recherche a ete finance par le Conseil de recherches en sciences naturelles et en genie du Canada [RGPIN-2014-06012]
- Canadian Foundation for Innovation
- John R. Evans Leaders Opportunity Fund
- Western College of Medicine, University of Saskatchewan
- College of Medicine, University of Saskatchewan
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Male courtship in Drosophila melanogaster is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons involved. Courtship involves a series of distinctive behavioral patterns, culminating in the final copulation step, where sperms from the male are transferred to the female. The duration of this process is tightly controlled by multiple genes. The fruitless (fru) gene is one of the factors that regulate the duration of copulation. Using several intersectional genetic combinations to restrict the labeling of GAL4 lines, we found that a subset of a serotonergic cluster of fru neurons co-express the dopamine-synthesizing enzyme, tyrosine hydroxylase, and provide behavioral and immunological evidence that these neurons are involved in the regulation of copulation duration.
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