Journal
FRONTIERS IN NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2018.00255
Keywords
autophagy; neurodegenerative disease; Alzheimer disease; tauopathy; Parkinson disease; amyotrophic lateral sclerosis; polyglutamine disease
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Funding
- MEXT of Japan [17H01533, 17H06414, 16K15230, 17H05691, 16K09668]
- Project for Cancer Research and Therapeutic Evolution (P-CREATE)
- Project for Psychiatric and Neurological Disorders from the Japan Agency for Medical Research and Development, AMED
- Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University
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Autophagy is a phylogenetically conserved mechanism that controls the degradation of subcellular constituents, including misfolded proteins, and damaged organelles. The progression of many neurodegenerative diseases is thought to be driven by the aggregation of misfolded proteins; therefore, autophagic activity is thought to affect disease severity to some extent. In some neurodegenerative diseases, the suppression of autophagic activity accelerates disease progression. Given that the induction of autophagy can potentially mitigate disease severity, various autophagy-inducing compounds have been developed and their efficacy has been evaluated in several rodent models of neurodegenerative diseases.
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