Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2017.00442
Keywords
dorsal striatum; medium spiny neurons; glycine receptors; tonic current; excitability
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Funding
- Interuniversity Attraction Pole from Belgian Science Policy Office (BELSPO) [IAP - P7/10]
- FRS-FNRS
- FMRE-Belgium
- Medical Research Council [G0500833]
- Medical Research Council [MR/J004049/1, G0500833] Funding Source: researchfish
- MRC [MR/J004049/1, G0500833] Funding Source: UKRI
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Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico-striato-thalamic loop, responsible for the initiation of voluntary movements and motor learning. GABAergic transmission exerts the main inhibitory control of MSNs. However, MSNs also express chloride-permeable glycine receptors (GlyRs) although their subunit composition and functional significance in the striatum is unknown. Here, we studied the function of GlyRs in MSNs of young adult mice. We show that MSNs express functional GlyRs, with alpha 2 being the main agonist binding subunit. These receptors are extrasynaptic and depolarizing at resting state. The pharmacological inhibition of GlyRs, as well as inactivation of the GlyR alpha 2 subunit gene hyperpolarize the membrane potential of MSNs and increase their action potential firing offset. Mice lacking GlyR alpha 2 showed impaired motor memory consolidation without any changes in the initial motor performance. Taken together, these results demonstrate that tonically active GlyRs regulate the firing properties of MSNs and may thus affect the function of basal ganglia.
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