Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2018.00169
Keywords
DNA Methylation; GADD45B; gene expression; synaptic plasticity; TET enzymes; base excision repair (BER); neural disorders; neurons
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [Kr1879/5-1/6-1/SFB779 TPB8]
- BMBF Energi'' [FKZ: 01GQ1421B]
- EU Joint Programme-Neurodegenerative Disease Research (JPND) project STAD
- Leibniz Foundation
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Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this minireview, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
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