Journal
FEBS OPEN BIO
Volume 8, Issue 3, Pages 332-338Publisher
WILEY
DOI: 10.1002/2211-5463.12364
Keywords
3UTR; alternative polyadenylation; breast cancer; Ki-67; miR-140-3p
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Funding
- National Natural Science Foundation of China [81072057, 81272800, 81702594]
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Ki-67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki-67 is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki-67 3'UTR results in the loss of the binding sites for the suppressive miRNAs and thus renders the transcript with a shortened 3'UTR insusceptible to miRNA-mediated suppression. This APA-mediated shortening of the Ki-67 3'UTR contributes to increased mRNA stability and enhanced translational efficiency. In summary, our results not only highlight the post-transcriptional regulation of Ki-67 involving APA and microRNAs but also suggest that Ki-67 3'UTR disruption could serve as a molecular marker in breast cancer.
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