Journal
ENVIRONMENTAL SCIENCE-NANO
Volume 5, Issue 5, Pages 1218-1230Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8en00189h
Keywords
-
Funding
- FRQNT [2015-PR-183946]
- FRQNT
- Groupe de recherche en physique et technologie des couches minces
- Division of Chemistry (CHE), National Science Foundation [NSF/CHE-1346572]
- Division of Materials Research (DMR), National Science Foundation [NSF/CHE-1346572]
- U.S. DOE [DE-AC02-06CH11357]
Ask authors/readers for more resources
The effect of low concentration (0.001 wt%) of charged silica nanoparticles (NPs) on the molecular structure of lung surfactant monolayers was investigated at the air/water interface using grazing incidence X-ray diffraction (GIXD) and X-ray reflectivity (XR). The lipid systems investigated included 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), mixtures of DPPC and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG), and Infasurf (a clinical lung surfactant formulation). In all cases, the anionic silica NPs interacted with the films but induced only small structural changes. By contrast, the cationic NPs induced a significant reduction of the alkyl chain tilt angle when anionic lipid was present. This appears to be associated with a condensation of the POPG lipids that would alter the ratio of liquid-expanded and condensed phases. Thus, this study reveals that low concentrations of cationic NPs can induce structural changes that could impact film mechanical properties that are important for pulmonary function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available