Journal
CURRENT CARDIOLOGY REPORTS
Volume 20, Issue 3, Pages -Publisher
SPRINGER
DOI: 10.1007/s11886-018-0961-3
Keywords
Extracellular volume; Computed tomography; Cardiovascular magnetic resonance; Tissue characterization
Categories
Funding
- British Heart Foundation Clinical Research Training Fellowship [FS/16/31/32185]
- University College London Hospitals NIHR Biomedical Research Centre and Biomedical Research Unit at Barts Hospital
- National Institute of Health Research (NIHR) [DRF-2013-06-102]
- British Heart Foundation [FS/16/31/32185] Funding Source: researchfish
- National Institute for Health Research [CL-2017-18-001, DRF-2013-06-102] Funding Source: researchfish
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Purpose of review This review article discusses the evolution of extracellular volume (ECV) quantification using both cardiovascular magnetic resonance (CMR) and computed tomography (CT). Recent findings Visualizing diffuse myocardial fibrosis is challenging and until recently, was restricted to the domain of the pathologist. CMR and CT both use extravascular, extracellular contrast agents, permitting ECV measurement. The evidence base around ECV quantification by CMR is growing rapidly and just starting in CT. In conditions with high ECV (amyloid, oedema and fibrosis), this technique is already being used clinically and as a surrogate endpoint. Non-invasive diffuse fibrosis quantification is also generating new biological insights into key cardiac diseases. Summary CMR and CT can estimate ECV and in turn diffuse myocardial fibrosis, obviating the need for invasive endomyocardial biopsy. CT is an attractive alternative to CMR particularly in those individuals with contraindications to the latter. Further studies are needed, particularly in CT.
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