4.5 Review

Tailoring Sensitivity in Electrochemical Nucleic Acid Hybridization Biosensing: Role of Surface Chemistry and Labeling Strategies

Journal

CHEMELECTROCHEM
Volume 6, Issue 1, Pages 60-72

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/celc.201800667

Keywords

nucleic acid-based electrochemical sensors; surface chemistry; formats; amplification; labeling

Funding

  1. Spanish Ministerio de Economia y Competitividad Research Projects [CTQ2015-70023-R, CTQ2015-64402-C2-1-R]
  2. NANOAVANSENS Program from the Comunidad de Madrid [S2013/MT3029]

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Electrochemical nucleic acid hybridization biosensors have become a mainstay to detect DNA or RNA targets of interest in clinical diagnostics, environmental monitoring and food quality control. Despite the great progress they demonstrated during the last years, there is a constant demand to improve their performance, mainly in terms of sensitivity, simplicity of protocols and easy implementation in routine and decentralized determinations. Within this context, the tremendous possibilities offered by both, a judicious interfacing of the electrode surface, and the use of innovative labeling strategies not requiring nanomaterials or nucleic acid amplification, is discussed critically in this review.

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