Journal
CANCER MEDICINE
Volume 7, Issue 5, Pages 2048-2063Publisher
WILEY
DOI: 10.1002/cam4.1405
Keywords
Feedback loop; laryngeal cancer; NF-kappa B; NF-kappa B interacting lncRNA; radioresistance
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Funding
- National Natural Science Foundation of China NSFC [81402502]
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Laryngeal cancer is one of the most common head and neck malignant tumors and is commonly resistant to X-ray-based radiotherapy. NF-kappa B interacting lncRNA (NKILA) has been reported to serve as a tumor suppressor in several cancers through combining with NF-kappa B: I kappa B complex thereby inhibiting NF-kappa B activation. Herein, we demonstrated a low NKILA expression in laryngeal cancer and its correlation with shorter overall survival in patients with laryngeal cancer. NKILA serves as a tumor suppressor in laryngeal cancer by suppressing laryngeal cancer cell viability and migration, whereas promoting cell apoptosis; NKILA knockdown reverses the cytotoxicity of X-ray radiation on laryngeal cancer cells through combining with NF-kappa B: I kappa B complex to inhibit I kappa B phosphorylation, inhibit p65 nuclear translocation, and finally inhibit NF-kappa B activation. NF-kappa B binds to the promoter region of NKILA to activate its transcriptional activity, upregulated NKILA then inhibits I kappa B phosphorylation and NF-kappa B activation, thus forming a negative feedback loop to sensitize laryngeal cancer cell to X-ray radiation. In conclusion, NKILA can serve as a promising agent of enhancing the cytotoxicity of X-ray radiation on laryngeal cancer and addressing the radioresistance of laryngeal cancer.
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