Journal
BONE & JOINT RESEARCH
Volume 7, Issue 3, Pages 232-243Publisher
BRITISH EDITORIAL SOC BONE JOINT SURGERY
DOI: 10.1302/2046-3758.73.BJR-2017-0270.R1
Keywords
Biomaterials; Bone; Fracture; Healing phases; Mineralization; Scaffold
Categories
Funding
- Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
- German Research Foundation [FOR 2165: DFG SCHM 2977]
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Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be challenged by a multitude of pathological conditions. While innovative approaches have helped to unravel the cascades of bone healing, this knowledge has so far not improved the clinical outcomes of bone defect treatment. Recent findings have allowed us to gain in-depth knowledge about the physiological conditions and biological principles of bone regeneration. Now it is time to transfer the lessons learned from bone healing to the challenging scenarios in defects and employ innovative technologies to enable biomaterial-based strategies for bone defect healing. This review aims to provide an overview on endogenous cascades of bone material formation and how these are transferred to new perspectives in biomaterial- driven approaches in bone regeneration.
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