Journal
ALLERGOLOGY INTERNATIONAL
Volume 67, Issue 2, Pages 191-194Publisher
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2017.09.003
Keywords
Chronic spontaneous urticaria (CSU); Endothelial cells; Extrinsic coagulation pathway eosinophils; Histamine; Tissue factor (TF)
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Funding
- SENSHIN Medical Research Foundation
- GSK Japan Research Grant 2016
- Japanese Society of Allergology
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Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H-1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria. Copyright (c) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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