Journal
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
Volume 7, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/wdev.309
Keywords
fetal wound healing; fibrosis; regenerative medicine; scarless; scarring; wound healing
Categories
Funding
- Stanford University Transplant and Tissue Engineering Center of Excellence
- Stanford University Child Health Research Institute
- American College of Surgeons Resident Research Scholarship
- Stanford University Tissue and Transplant Engineering Center of Excellence Program Fellowship
- Society of University Surgeons Resident Scholar Award
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Since the discovery of scarless fetal skin wound healing, research in the field has expanded significantly with the hopes of advancing the finding to adult human patients. There are several differences between fetal and adult skin that have been exploited to facilitate scarless healing in adults including growth factors, cytokines, and extracellular matrix substitutes. However, no one therapy, pathway, or cell subtype is sufficient to support scarless wound healing in adult skin. More recently, products that contain or mimic fetal and adult uninjured dermis were introduced to the wound healing market with promising clinical outcomes. Through our review of the major experimental targets of fetal wound healing, we hope to encourage research in areas that may have a significant clinical impact. Additionally, we will investigate therapies currently in clinical use and evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent. WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309 This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Plant Development > Cell Growth and Differentiation Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells
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