Journal
EXPERIMENTAL HEMATOLGY & ONCOLOGY
Volume 1, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/2162-3619-1-34
Keywords
Radioimmunotherapy; Rat colon carcinoma; Lu-177; Antigen expression; Metastasis
Categories
Funding
- Swedish Research Council
- Swedish Cancer Society
- Mrs. Berta Kamprad's Foundation
- Gunnar Nilsson's Foundation
- Crafoord Foundation
- Government Funding of Clinical Research within National Health Service
- King Gustaf V's Jubilee Foundation
- Lund University Medical Faculty Foundation
- Lund University Hospital Fund
Ask authors/readers for more resources
Background: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors. Findings: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg Lu-177-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors. No tumors completely lacked positively stained tumor cells. Conclusions: Although it was not possible to demonstrate that the antigen reduction is triggered by the radioimmunotherapy this result stress the importance of considering the risk of reduced antigen expression in metastases after radioimmunotherapy prior to further targeted therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available