Journal
CASE REPORTS IN DERMATOLOGY
Volume 4, Issue 3, Pages 215-221Publisher
KARGER
DOI: 10.1159/000343881
Keywords
Trichilemmal carcinoma; Spontaneous regression; Granulysin
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Funding
- Grants-in-Aid for Scientific Research [24791133] Funding Source: KAKEN
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We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.
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