A Review on the Electrochemically Self-organized Titania Nanotube Arrays: Synthesis, Modifications, and Biomedical Applications

Titania nanotubes grown by anodic oxidation have intrigued the material science community by its many unique and potential properties, and the synthesis of technology is merging to its mature stage. The present review will focus on TiO2 nanotubes grown by self-organized electrochemical anodization from Ti metal substrate, which critically highlights the synthesis of this type of self-organized titania nanotube layers and the means to influence the size, shape, the degree of order, and crystallized phases via adjusting the anodization parameters and the subsequent thermal annealing. The relationship between dimensions and properties of the anodic TiO2 nanotube arrays will be presented. The latest progress and significance of the research on formation mechanism of anodic TiO2 nanotubes are briefly discussed. Besides, we will show the most promising applications reported recently in biomedical directions and modifications carried out by doping, surface modification, and thermal annealing toward improving the properties of anodically formed TiO2 nanotubes. At last, some unsolved issues and possible future directions of this field are indicated.