Journal
NANOSCALE RESEARCH LETTERS
Volume 13, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-018-2432-6
Keywords
Graphene oxide; Poly(lactic-co-glycolic acid); Collagen; Nano-hydroxyapatite; Biodegradable porous scaffold; Bone tissue engineering
Funding
- National Natural Science Foundation of China [31600753, 51201056, 51171058, 51401146]
- Natural Science Foundation of Tianjin [16JCYBJC43400]
- National Science Foundation of Hebei [C2017202206]
- Hebei Province Foundation for Returned Overseas Chinese Scholars [CL201711]
- Natural Science Foundation of Hebei Province of China [E2013202021, E2013202022, E2015202037]
- Outstanding Youth Foundation of Hebei Province of China [E2015202282]
- Science and Technology Correspondent Project of Tianjin [14JCTPJC00496, 15JCYBJC29900]
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Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young's modulus of the 1.5 wt% GO incorporated scaffold is greatly increased compared to the control sample. The in vitro experiments show that the nHAC/PLGA/GO (1.5 wt%) scaffolds significantly cell adhesion and proliferation of osteoblast cells (MC3T3-E1). This present study indicates that the nHAC/PLGA/GO scaffolds have excellent cytocompatibility and bone regeneration ability, thus it has high potential to be used as scaffolds in the field of bone tissue engineering.
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