Journal
WORLD JOURNAL OF DIABETES
Volume 3, Issue 1, Pages 19-28Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v3.i1.19
Keywords
Nuclear factor (erythroid-derived2)-like 2; Oxidative stress; Insulin resistance; Metabolism; Diabetic drug
Categories
Funding
- Canadian Institutes of Health Research [89887]
- NSFC [81072300, 30730079]
Ask authors/readers for more resources
Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho- physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications. (C) 2012 Baishideng. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available