Journal
MICROMACHINES
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/mi9060274
Keywords
label-free sensor; optofluidic microbubble resonator; detection of small molecules
Categories
Funding
- Special Project of National Key R&D Program of the Ministry of Science and Technology of China [2106YFC0201401]
- National Natural Science Foundation of China (NSFC) [61505032, 61378080, 61327008]
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The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.
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