Journal
NATURE REVIEWS CANCER
Volume 12, Issue 2, Pages 121-132Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3204
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Funding
- Cancer Research UK [C1443/A12750, C1443/A6721]
- Wellcome Trust [094, 409]
- European Union FP7 `Inflacare' consortium
- Leukemia and Lymphoma Research [11022]
- Cancer Research UK [12750] Funding Source: researchfish
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It is only recently that the full importance of nuclear factor-kappa B (NF-kappa B) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-kappa B activation, it is now becoming clear that the inhibitor of NF-kappa B kinases (IKKs), which regulate NF-kappa B activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-kappa B pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-kappa B subunits.
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