Journal
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 111, Issue 4, Pages 350-364Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djy132
Keywords
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Categories
Funding
- Cancer Research - UK [C12292/A20861, C12292/A11174]
- iCOGS: the European Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- Cancer Research UK [C12292/A11174, C1287/A10118, C1287/A 10710, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C5047/A8385]
- National Institutes of Health [CA128978]
- Post-Cancer GWAS initiative (GAME-ON initiative) [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR) [CRN-87521]
- Ministry of Economic Development, Innovation and Export Trade [PSR-SIIRI-701]
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- Government of Canada through Genome Canada
- Canadian Institutes of Health Research
- Ministry of Economy, Science and Innovation through Genome Quebec
- Quebec Breast Cancer Foundation
- National Cancer Institute [BCFR: UM1 CA164920]
- BFBOCC: Lithuania (BFBOCC-LT): Research Council of Lithuania [SEN-18/2015]
- BIDMC: Breast Cancer Research Foundation
- BMBSA: Cancer Association of South Africa
- FEDER funds [PI16/00440]
- Spanish Ministry of Economy and Competitiveness (MINECO) [SAF2014-57680-R]
- Spanish Research Network on Rare diseases (CIBERER)
- National Cancer Institute of the National Institutes of Health from the National Cancer Institute [R25CA112486, RC4CA153828]
- Office of the Director, National Institutes of Health
- CONSIT: Associazione Italiana Ricerca sul Cancro (AIRC) [15547]
- Italian Association for Cancer Research (AIRC) [16933]
- Associazione Italiana Ricerca sul Cancro (AIRC) [16732]
- Fondazione IRCCS Istituto Nazionale Tumori
- DEMOKRITOS: European Union (European Social Fund -ESF)
- Greek national funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSRF) -Research Funding Program of the General Secretariat for Research Technology [SYN11_10_19 NBCA]
- Investing in Knowledge Society through the European Social Fund
- EMBRACE: Cancer Research UK [C1287/A10118, C1287/A11990]
- NIHR
- FCCC: The University of Kansas Cancer Center [P30 CA168524]
- Kansas Bioscience Authority Eminent Scholar Program
- Chancellors Distinguished Chair in Biomedical Sciences Professorship
- FPGMX [FISPI05/2275]
- Mutua Madrilena Foundation (FMMA)
- GC-HBOC: German Cancer Aid [110837]
- European Regional Development Fund
- Free State of Saxony, Germany (LIFE Leipzig Research Centre for Civilization Diseases) [713-241202, 14505/2470, 14575/2470]
- GEORGETOWN: the Non-Therapeutic Subject Registry Shared Resource at Georgetown University (NIH/NCI) [P30-CA05100]
- Fisher Center for Hereditary Cancer and Clinical Genomics Research
- Swing For the Cure
- IWT
- European Regional Development FEDER funds [PI15/00059, PI16/01292, CB-161200301 CIBERONC]
- HEBCS: Helsinki University Hospital Research Fund
- Academy of Finland [266528]
- Finnish Cancer Society
- Sigrid Juselius Foundation
- HEBON: the Dutch Cancer Society [NKI1998-1854, NKI2004-3088, NKI2007-3756]
- Netherlands Organization of Scientific Research [NWO 91109024]
- Pink Ribbon grants [110005, 2014-187]
- BBMRI [NWO 184.021.007/CP46]
- Transcan grant JTC 2012 Cancer [12-054]
- National Institute of Health [1R 03CA130065]
- North California Cancer Center
- HUNBOCS: Hungarian Research Grants [KTIA-OTKA CK-80745, OTKA K-112228]
- Asociacion Espanola Contra el Cancer (AECC)
- Instituto de Salud Carlos III (organismo adscrito al Ministerio de Economia y Competitividad)
- Fondo Europeo de Desarrollo Regional (FEDER), una manera de hacer Europa [PI10/01422, PI13/00285, PIE13/00022, PI15/00854, PI16/00563]
- Autonomous Government of Catalonia (PERIS Project MedPerCan)
- Autonomous Government of Catalonia [PI13/00285, PIE13/00022, PI15/00854, PI16/00563, ISCIIIRETIC RD06/0020/1051, RD12/0036/008, 2009SGR283, 2009SGR290, 2014SGR338]
- IHCC [PBZ_ KBN_ 122/P05/2004]
- INHERIT: Canadian Institutes of Health Research [CRN-87521]
- MAYO: NIH [CA116167, CA192393, CA176785, F32CA162847]
- NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201, CA125183, R01 CA142996, 1U01CA161032]
- European Union Seventh Framework Programme (2007Y2013)/European Research Council [310018]
- MODSQUAD: MH CZ-DRO (MMCI) [00209805]
- Charles University in Prague project [UNCE204024]
- Cancer Center Support Grant/Core Grant [P30 CA008748]
- NAROD [1R01 CA149429-01]
- Westat, Inc, Rockville, MD [NO2-CP-11019-50, N02-CP-21013-63, N02-CP-65504]
- NNPIO: the Russian Federation for Basic Research [15-04-01744, 16-54-00055, 17-54-12007]
- NRG Oncology [U10 CA180868]
- NRG SDMC grant [U10 CA180822]
- NRG Tissue Bank [CA 27469]
- NRG Statistical and Data Center [CA 37517]
- Intramural Research Program, NCI
- PBCS: Italian Association of Cancer Research (AIRC) [14477]
- Tuscany Institute for Tumors (ITT) grant [2014-2015-2016]
- Ministry of Higher Education [UM. C/HlR/MOHE/06]
- Cancer Research Initiatives Foundation
- UCHICAGO: NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA125183]
- American Cancer Society [MRSG-13-063-01-TBG, CRP-10-119-01-CCE]
- Susan G. Komen Foundation [SAC110026]
- Ralph and Marion Falk Medical Research Trust
- Entertainment Industry Fund National Women's Cancer Research Alliance
- UCLA: Jonsson Comprehensive Cancer Center Foundation
- American Cancer Society Early Detection Professorship [SIOP-06-258-01-COUN]
- National Center for Advancing Translational Sciences (NCATS) [UL1TR000124]
- NIH [F32CA162847]
- DFKZ: German Cancer Research Center
- GEMO: Ligue Nationale Contre le Cancer
- Association Le cancer du sein, parlons-en! Award
- French National Institute of Cancer (INCa)
- HRBCP: Hong Kong Sanatorium and Hospital
- Dr Ellen Li Charitable Foundation
- Kerry Group Kuok Foundation
- Institut Catala de la Salut
- Asociaci on Espanola Contra el Cancer
- Spanish Health Research Foundation
- Carlos III Health Institute
- Ministerio de Economia y Competitividad
- Fondo Europeo de Desarrollo Regional (FEDER), una manera de hacer Europa
- Catalan Health Institute
- ILUH: Icelandic Association Walking for Breast Cancer Research
- Landspitali University Hospital Research Fund
- IOVHBOCS: Ministero della Salute
- 5 x 1000 Istituto Oncologico Veneto grant
- IPOBCS: Liga Portuguesa Contra o Cancro
- kConFab: The National Breast Cancer Foundation
- Queensland Cancer Fund
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- MCGILL: Jewish General Hospital Weekend to End Breast Cancer, Quebec Ministry of Economic Development, Innovation and Export Trade
- MSKCC: the Breast Cancer Research Foundation
- Robert and Kate Niehaus Clinical Cancer Genetics Initiative
- Andrew Sabin Research Fund
- NCI: the Intramural Research Program of the US National Cancer Institute, NIH
- NICCC: Clalit Health Services in Israel
- Israel Cancer Association
- Breast Cancer Research Foundation (BCRF), New Yotk, NY
- NRG Administrative Office
- OSUCCG: Ohio State University Comprehensive Cancer Center
- SEABASS: Ministry of Science, Technology and Innovation
- SMC: the Israeli Cancer Association
- SWE-BRCA: the Swedish Cancer Society
- UCSF: UCSF Cancer Risk Program
- Helen Diller Family Comprehensive Cancer Center
- UKFOCR: Cancer Research UK
- UPENN: National Institutes of Health (NIH)
- Susan G. Komen Foundation for the Cure
- Basser Center for BRCA
- UPITT/MWH: Hackers for Hope Pittsburgh
- VFCTG: Victorian Cancer Agency
- Cancer Australia
- National Breast Cancer Foundation
- [R0 1CA140323]
- [R01 CA214545]
- [MEYSNPS I - LO1413]
- NATIONAL CANCER INSTITUTE [ZIACP010144] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. Results: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m(2) increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. Conclusion: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
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