Journal
ENDOCRINE
Volume 41, Issue 1, Pages 111-115Publisher
HUMANA PRESS INC
DOI: 10.1007/s12020-011-9510-1
Keywords
Graves' disease; Hashimoto's thyroiditis; CD40; CTLA-4; Single nucleotide polymorphisms (SNPs)
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Funding
- National Natural Science Foundation of China [30871185]
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This study was to investigate whether the common polymorphisms of CD40 and CTLA4 genes confer susceptibility to AITD in the Chinese population. A set of unrelated subjects including 303 GD patients, 208 HT patients, and 215 matched healthy controls were recruited. SNPs were genotyped by the method of PCR-RFLP. (1) As for CD40 C/T-1 SNP, only a significant difference was found in allele frequencies between GD and control groups (P = 0.033). (2) On the part of CTLA-4 A/G(49) SNP, significant differences were found in genotype and allele frequencies between GD and control groups (P = 7.0 x 10(-5) and P = 0.002, respectively), and similar results were found between HT and control groups (P = 0.015 and P = 0.003, respectively). (3) The logistic regression analysis showed there was no interaction between CD40 and CTLA4 genotypes (P = 0.262). These results indicate that both CTLA-4 A/G(49) and CD40 C/T-1 SNPs are associated with genetic susceptibility of GD, and CTLA-4 A/G(49) is also associated with HT.
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