Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12951-018-0366-x
Keywords
Gold nanoparticles; Crushed gold shells; Radioactive iodine-124; Nuclear medicine imaging; Cerenkov luminescent imaging; Tumor imaging; Passive targeting
Funding
- National Research Foundation of Korea (NRF) grants - Korea government (MSIP)
- Korea Health technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI16C1501]
- Medical Cluster R&D Support Project through the Daegu-Gyengbuk Medical Innovation Foundation (DGMIF) - Ministry of Health Welfare [HT16C0001, HT16C0002, HT17C0009]
- National Research Foundation of Korea (NRF) grant - Korea Government (MSIP) [2014R1A1A1003323, 2017R1D1A1B03028340]
- Radiation Technology R&D program through the National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [NRF-2012M2A2A7013480]
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Background: Radioactive isotope-labeled gold nanomaterials have potential biomedical applications. Here, we report the synthesis and characterization of PEGylated crushed gold shell-radioactive iodide-(124)-labeled gold core nanoballs (PEG-I-124-Au@AuCBs) for in vivo tumor imaging applications through combined positron emission tomography and Cerenkov luminescent imaging (PET/CLI). Results: PEG-I-124-Au@AuCBs showed high stability and sensitivity in various pH solutions, serum, and in vivo conditions and were not toxic to tested cells. Combined PET/CLI clearly revealed tumor lesions at 1 h after injection of particles, and both signals remained visible in tumor lesions at 24 h, consistent with the biodistribution results. Conclusion: Taken together, the data provided strong evidence for the application of PEG-I-124-Au@AuCBs as promising imaging agents in nuclear medicine imaging of various biological systems, particularly in cancer diagnosis.
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