Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 29, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00729b
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Funding
- National Natural Science Fund [61435010, 61575089, 81470868]
- Science and Technology Innovation Commission of Shenzhen [KQTD2015032416270385, JCYJ20150625103619275]
- Science and Technology Planning Project of Guangdong Province [2016B050501005]
- Educational Commission of Guangdong Province [2016KCXTD006]
- China Postdoctoral Science Foundation [2017M612730]
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Two-dimensional (2D) inorganic nanomaterials for biomedical applications still face the challenge of simultaneously offering a high photothermal conversion efficiency (PTCE), efficient drug delivery, biocompatibility and biodegradability. Herein, cancer treatment using tin sulfide nanosheet (SnS NS)-based dual therapy nano-platforms (SDTNPs), including photothermal- and chemo-therapy, is demonstrated. SnS, a black phosphorus (BP) analogue binary IV-VI compound, was synthesized using liquid phase exfoliation. SnS NSs comprising 2-4 layers exhibited good biocompatibility and a high PTCE of 39.3%, which is higher than other popular 2D materials. The SnS NSs showed a stable photothermal performance over 2 h of laser irradiation and exhibited approximate to 14% degradation after 10 h of irradiation. It was also found that SnS NSs show high loading of small molecules such as doxorubicin (DOX) (up to approximate to 200% in weight). Consequently, the SDTNPs achieved notable tumor therapy through the combination of photothermal- and chemo-therapy both in vitro and in vivo. Our study may pave the way for the biomedical application of SnS and other IV-VI compound-based 2D nanomaterials. Compared with traditional therapies, SnS NS-based laser therapy is green and efficient, due to its biocompatibility, photo-degradability, high efficiency photothermal properties and high drug loading.
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