Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 25, Pages 4232-4238Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01152d
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Funding
- National Natural Science Foundation of China [21708030]
- Fundamental Research Funds for the Central University [2682016CX102]
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Biothiols and SO2 play crucial roles in many physiological and pathological processes. To unravel their complicated interrelationship and cellular cross-talk, it would be highly desirable to develop single-molecule fluorescent probes that can selectively detect biothiols and SO2 via different emission channels. Here, a novel chromenylium derivative, BPO-Py-diNO(2), based on the rational design of dual recognition sites for biothiols and SO2 selectively and sensitively responded to biothiols with near-infrared fluorescence, and to SO2 with green fluorescence. The emission shift for the two channels was 170 nm. BPO-Py-diNO(2) was selectively enriched in lysosomes. It could also be used to evaluate dual-channel imaging of endogenous biothiols and SO2 in living HeLa cells, and it could be used for monitoring the mutual interconversion of biothiols and SO2.
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